Tramadol hydrochloride (tramadol) is an opioid analgesic drug which The central work. Tramadol inhibits re-uptake (re-uptake) norepinephrine and 5-hydroxytryptamine threshold of nerve fibers, facilitating the release f 5-hydroxytryptamine and activates µ-opioid receptors, and little influenced or ? receptors.
All these mechanisms would affect the central regulation temperature. Therefore, these drugs can be used to prevent post-anesthetic shivering.The advantage gained by using tramadol in addition to the influence of hemodynamic bermaknan not they cause respiratory depression and less sedation compared with meperidine. So it can be said to use more secure, especially in patients with cardiorespiratory conditions who not good. Besides, the incidence of nausea and vomiting are relatively smaller than meperidine.
Bhatnagar et al. using a dose of 1 mg / kg intravenously to treat the incidence of post-anesthetic shivering and get the 80% patients stopped shivering in a span of 10 minutes after the drug is administered. S. Mathews et al. who conducted the study using a dose of tramadol mg / kg and 2 mg / kg given at the start of wound closure in patients who underwent general anesthesia conclude that tramadol effectively and secure to prevent the occurrence of post-anesthetic shivering. The same is shown by the results of the study De Witte et al., but with a dose of 3 mg / kg.
Tsai YC et al. conduct research using tramadol dose of 0.5 mg / kg body weight intravenously to prevent shivering after epidural anesthesia. The results obtained tramadol apparently have the same effectiveness with meperidine dose of 0.5 mg / kg iv in preventing shivering after epidural anesthesia. While AMH Chan et al. conclude tramadol dose of 0.25 mg / kg intravenously effective overcome shivering in cesarean patients who performed regional anesthesia Cesarea with minimal side effects.
Buy Tramadol without prescriptions