Tramadol HCl is a synthetic opioid and is included in group aminosikloheksan is efficacious as an analgesic or antinyeri. tramadol HCl characteristics that support for slow-release preparations made ??15 among other things that do not use too large a dose of 100 mg, absorbed well in the stomach, the half-life of 5.5 hours and have good stability in water and ethanol (Anonymous, 2004).
One reason for tramadol HCl made ??in the slow-release preparations are association as an analgesic medication for chronic diseases. patients with Chronic diseases tend to use drugs on a regular basis with frequency of more than 2 times a day and in the long term. In order to enhance patient comfort, the tramadol HCl made ??in slow-release preparations.
One method is the simplest and often used in manufacture of slow-release preparation is a matrix system, where the active substance is mixed homogeneously in the matrix (solid carrier). Metolose 90SH ®(cellulose derivative) which is hydrophilic. matrix form a hydrophilic gel is widely used to inhibit the release extended drug because it is like water (hydrophilic), although stable is hygroscopic after drying, is stable in old water, and reduce the risk of dose dumping (Huang, et al., 2004; Harwood, 2005).
The results Kurniawati (2005) proved that the increase concentration of methocel K4M Premium EP matrix used influence of granular flow properties. The more the number of methocel K4M Premium EP to used lower speeds. Use of methocel K4M Premium EP with levels of 30% has the ability to inhibit The best drug release.
