Premature ejaculation is a condition in which a man ejaculates sooner than normal ejaculation time, or too fast for couples sexual relationship, with the IELT (intravaginal ejaculation latency time) = 2 min at 80% sexual relationship. Premature ejaculation is the most common sexual dysfunction, affecting approximately 23% of men aged 18-75 years.
Tramadol, an opioid class of drugs known efficacious as an analgesic, is shown to have relatively good safety profile during the 30 years of its use in humans. In addition, as an analgesic, tramadol mechanism of action was also useful to delay ejaculation. Tramadol is known to work as an agonist at ยต-opioid receptor, serotonin release, and inhibit re-uptake (reuptake) of norepinephrine. Efficacy as a cure premature ejaculation appears to be associated with the last two mechanisms.
Phase II clinical trial showed that tramadol is an effective drug, with minimal side effects, for men with premature ejaculation. Men who ate tramadol had significantly longer IELT, improved ejaculation control, increased sexual satisfaction, as well as domestic relations problems are much less compared to placebo. Comparison of clinical data by a pharmaceutical company suggests that tramadol has a better efficacy than dapoxetine, an SSRI class of antidepressants (selective serotonin reuptake inhibitors) which is the first oral drug approved for the indication of premature ejaculation. In addition, the SSRI class of drugs considered to have more serious side effects. However, dapoxetine should be used only if needed when going on a sexual relationship, and need not be consumed regularly.
Another study conducted by EA Salem et al. in 2008 showed that 25 mg tramadol is useful for cases of premature ejaculation. Tramadol HCl 25 mg administered in the first group (n = 30) before sexual intercourse, while the second group was given placebo (n = 30). Therapy administered for 8 weeks. Drugs taken 1-2 hours before sexual activity, and patients were asked to have sex at least once a week. The average initial value of IELT before treatment was 1.17 + / - 0.39 minutes. At the time the patients received tramadol, an average IELT increased significantly to 7.37 + / - 2.53 minutes. When given a placebo, the mean IELT of only 2.01 + / - 0.71 minutes. All patients also reported that they were satisfied with their ejaculatory control.
Conclusion, tramadol HCl at a dose of 25-50 mg can be used as a cure for premature ejaculation.
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