Tramadol HCl is one type of analgesic drugs, which are used to cope with severe pain either acute or chronic pain after surgery.Tramadol HCl has some characteristics such as the use of doses which is not too large, namely 100 mg, 5.5 hour half-life, absorbed with either in the stomach, has a price of 9.14 pKa, log P of 1.35 at pH 7 and have good stability in water and ethanol (Anonymous, 2004).
One reason for tramadol HCl made ??in the slow-release preparations are association as an analgesic medication for chronic diseases. patients with Chronic diseases tend to use drugs on a regular basis with frequency of more than 2 times a day and in the long term. In order to enhance patient comfort, the tramadol HCl made ??in slow-release preparations. One method used in the manufacture of slow-release preparations is a matrix system where the drug is mixed homogeneously with the matrix material. One advantage of the matrix system is its use of elatively simple and inexpensive compared to other systems.
The research was conducted with the addition of matrix to slow release of active substances. Matrix used in this study is metolose 90SH®. Metolose 90SH® a hydrophilic matrix which can form a hydrogel layer is thick all around on the slow-release preparations after contact with gastrointestinal fluids. Hydrogel layer is capable of blocking the release of active substance in the preparation so that the rate of drug release can be controlled (Kavanagh and Corrigan, 2004). The advantage of this matrix is a character who likes water (hydrophilic), although it is hygroscopic stable after drying, and is stable in cold water (Harwood, 2005; Huang, et al., 2004).
One reason for tramadol HCl made ??in the slow-release preparations are association as an analgesic medication for chronic diseases. patients with Chronic diseases tend to use drugs on a regular basis with frequency of more than 2 times a day and in the long term. In order to enhance patient comfort, the tramadol HCl made ??in slow-release preparations. One method used in the manufacture of slow-release preparations is a matrix system where the drug is mixed homogeneously with the matrix material. One advantage of the matrix system is its use of elatively simple and inexpensive compared to other systems.
The research was conducted with the addition of matrix to slow release of active substances. Matrix used in this study is metolose 90SH®. Metolose 90SH® a hydrophilic matrix which can form a hydrogel layer is thick all around on the slow-release preparations after contact with gastrointestinal fluids. Hydrogel layer is capable of blocking the release of active substance in the preparation so that the rate of drug release can be controlled (Kavanagh and Corrigan, 2004). The advantage of this matrix is a character who likes water (hydrophilic), although it is hygroscopic stable after drying, and is stable in cold water (Harwood, 2005; Huang, et al., 2004).
